Ciliary neurotrophic factor (CNTF) is structurally related to IL-6, IL-11, LIF, CLC, and OSM. CNTF was initially identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. Subsequent studies have demonstrated that CNTF is a survival factor for additional neuronal cell types, including dorsal root ganglion sensory neurons, sympathetic ganglion neurons, embryonic motor neurons, major pelvic ganglion neurons and hippocampal neurons.
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- Yuko Suzuki, Itaru Mizoguchi and Nobuhiko Uchida. (2007). “Detection of neurotrophic factors in taste buds by laser capture microdissection, immunohistochemistry, and in situ hybridization”. Arch. Histol. Cytol., Vol. 70: 117-126. doi: 10.1679/aohc.70.117
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