The high-affinity CNTF receptor complex, which mediates the biological action of CNTF, contains the ligand-binding alpha subunit (CNTF R alpha) and two signal-transducing proteins, LIF R beta and gp130. Whereas LIF R beta and gp130 are widely expressed in many cell types, the expression of CNTF R alpha is restricted to the central and peripheral nervous systems. cDNAs encoding CNTF R alpha isolated from both human and rat share 96% amino acid sequence identity.
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- Yuko Suzuki, Itaru Mizoguchi and Nobuhiko Uchida. (2007). “Detection of neurotrophic factors in taste buds by laser capture microdissection, immunohistochemistry, and in situ hybridization”. Arch. Histol. Cytol., Vol. 70: 117-126. doi: 10.1679/aohc.70.117
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