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Cathepsin D is a lysosomal aspartic protease of the pepsin family. Human Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 1 18), a propeptide (residues 19 64), and a mature chain (residues 65 412). The mature chain can be processed further to the light (residues 65 161) and heavy (residues 169 412) chains. It is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides.
Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer and possibly Alzheimer's disease
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- Barbara Ahlemeyer, Sascha Halupczok, Elke Rodenber-Frank, Klaus-Peter Valerius, and Eveline Baumgart-Vogt. (2018) Endogenous Murine Amyloid-β Peptide Assembles into Aggregates in the Aged C57BL/6J Mouse Suggesting These Animals as a Model to Study Pathogenesis of Amyloid-β Plaque Formation. Journal of Alzheimer's Disease, vol. 61, no. 4, pp. 1425-1450, 2018. DOI: 10.3233/JAD-170923
- Jianjian Shi, Lumin Zhang, Yi-Wei Zhang, Michelle Surma, R. Mark Payne, and Lei Wei. (2012). Down-regulation of doxorubicin-induced myocardial apoptosis accompanies postnatal heart maturation. American Journal of Physiology, doi: 10. 1152/ ajpheart. 00844. 2011
- Ramaswamy Kannappan, Youichi Satoh, Naoko Iriyama, Masayuki Ando, Michiko Takagi Sawada, Nobuaki Takahashi, Kimio Furuhata and Yutaka Uda. (2008). Identification and Characterization of Cathepsin D in a Highly Purified Sialidase from Starfish A. pectinifera. Journal of Biochemistry, 143(1):117-122; doi: 10.1093/jb/mvm199
- V. Lehmensiek, S.D. Süssmuth, J. Brettschneider, G. Tauscher, S. Felk, F. Gillardon, H. Tumani. (2007). Proteome analysis of cerebrospinal fluid in Guillain–Barré syndrome (GBS). Journal of Neuroimmunology, doi: 10.1016/j.jneuroim.2007.01.022
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