Parkin-1 and 2 contain an N-terminal ubiquitin-like domain, a linker region, and a C-terminal TRIAD domain consisting of two RING finger motifs flanking a cysteine-rich IBR motif. Mutations in Parkin are a major cause of autosomal recessive juvenile Parkinsonism. Parkin-2 lacks exon 5 which encodes amino acid residues 179 - 206 of Parkin.
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