Cathepsin L is a lysosomal cysteine protease expressed in most eukaryotic cells. Cathepsin L is known to hydrolyze a number of proteins, including the proform of urokinase-type plasminogen activator, which is activated by Cathepsin L cleavage. Cathepsin L has also been shown to proteolytically inactivate a1-antitrypsin and secretory leucoprotease inhibitor, two major protease inhibitors of the respiratory tract.
Cathepsin L has been implicated in several pathologic processes, including rheumatoid arthritis, muscular dystrophy, Alzheimers, cancer, myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria.
- Product Reviews
- Product Publications
- Jonas Weber, Joseph McInnes, Cise Kizilirmak, Maren Rehders, Maria Qatato, Eva K. Wirth, Ulrich Schweizer, Francois Verrey, Heike Heuer, Klaudia Brix. (2017). Interdependence of thyroglobulin processing and thyroid hormone export in the mouse thyroid gland. European Journal of Cell Biology, doi: 10.1016/j.ejcb.2017.02.002
- Tripti Tamhanea, Brit K. Woltersa, Rukshala Illukkumburaa, Gunhild M. Maelandsmob, Mads H. Haugena, Klaudia Brixa. (2015). Construction of a plasmid coding for green fluorescent protein tagged cathepsin L and data on expression in colorectal carcinoma cells. Data in Brief, doi: 10.1016/j.dib.2015.09.022
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size CARD8 RA30062 50 ug CARD9 RA30063 50 ug Caspase-10/b-Flice 2 RA15047 100 ug Caspase-12 RA15048 100 ug Caspase-14 RA30061 50 ug Caspase-3 GT15044 100 ug Caspase-3, active RA15046 50 ug Caspase-7 MO25036 100 ul Caspase-9 GT15045 100 ul Caspase-9 GT15045 50 ul Cathepsin B (Human) GT15046 100 ug Cathepsin B (Mouse) GT15047 100 ug Cathepsin D GT15042 100 ug Cathepsin F MO15096 500 ug Cathepsin G MO20021 100 ul Cathepsin L (Human) GT15048 100 ug Cathepsin O GT15197 100 ug Cathepsin S GT15198 100 ug Cathepsin V GT15199 100 ug