Product Details
Catalog Number: GT15053
Applications: ICC, WB, IHC, E
Type: Goat IgG
Immunogen: Recombinant human BMP-2
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Rat
Entrez: 650
UniProt: P12643
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

There are at least 20 structurally and functionally related BMPs, which are members of the TGF-beta superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. They are also involved in embryogenesis and morphogenesis of various tissues and organs. BMPs regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Similar to other TGF-beta family proteins, BMPs are highly conserved across animal species. 

BMP2 and 4 interact with GREM2 and SOSTDC1 and induce bone and cartilage formation. BMP4 also acts in mesoderm induction, tooth development, limb formation and fracture repair.

Images

At 45 days, the bone mineralization rates of the (A) rhBMP-2/CPC and the (B) rhBMP-2/GM/CPC groups were greater than those of the (C) untreated group, and the rates of the rhBMP-2/GM/CPC group were greater than those of the rhBMP-2/CPC group. However, there were no differences in the mineralization rates among the (D) rhBMP-2/CPC, (E) rhBMP-2/GM/CPC, and (F) untreated groups at 140 days (Double fluorescent labeling; original magnification, ×100). doi: 10.1007/s11999-010-1321-9

At 45 days, the bone mineralization rates of the (A) rhBMP-2/CPC and the (B) rhBMP-2/GM/CPC groups were greater than those of the (C) untreated group, and the rates of the rhBMP-2/GM/CPC group were greater than those of the rhBMP-2/CPC group. However, there were no differences in the mineralization rates among the (D) rhBMP-2/CPC, (E) rhBMP-2/GM/CPC, and (F) untreated groups at 140 days (Double fluorescent labeling; original magnification, ×100). doi: 10.1007/s11999-010-1321-9