Product Details
Catalog Number: GT15055
Applications: WB, IHC
Type: Goat IgG
Dilutions: IHC 5-15 ug/ml; WB 01. - 0.2 ug/ml; E 0.5 - 1.0 ug/ml
Immunogen: Recombinant human Contactin-1
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Entrez: 1272
UniProt: Q12860
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ug$365.00Add to Cart

Contactins mediate cell surface interactions during the development of the nervous system. Contactin 1 plays a role in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signalling between axons and myelinating glial cells. Contactin 1 also acts as an activating ligand for Notch1, leading to generation of oligodendrocytes. Its interaction with TNR induces neuronal repulsion and an inhibition of neural outgrowth. Contactin 1 shares the L2/HNK carbohydrate epitope with L1, N-CAM, MAG and other cell adhesion molecules from nervous tissue.

Images

Loss of TrkB in the cerebellum results in reduction of Contactin-1 localization on Golgi and granule cells. A, B, Loss of TrkB results in reduced localization of Contactin-1 in the IGL of P21 Wnt1::Cre;TrkBfl/fl mice (B) compared with control (A). C, D, Quantification of the area ratio of Contactin-1:vGluT1 (C) and the intensity of Contactin-1 expression (D) expression in control and Wnt1::Cre;TrkBfl/fl mice. For E–T, yellow represents only colocalized Contactin-1 on individual markers in blue

Loss of TrkB in the cerebellum results in reduction of Contactin-1 localization on Golgi and granule cells. A, B, Loss of TrkB results in reduced localization of Contactin-1 in the IGL of P21 Wnt1::Cre;TrkBfl/fl mice (B) compared with control (A). C, D, Quantification of the area ratio of Contactin-1:vGluT1 (C) and the intensity of Contactin-1 expression (D) expression in control and Wnt1::Cre;TrkBfl/fl mice. For E–T, yellow represents only colocalized Contactin-1 on individual markers in blue