Product Details
Catalog Number: GT15057
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: Recombinant mouse p75/NGF Receptor extracellular domain
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse, Rat, Porcine
Entrez: 4804
UniProt: P08138
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

The low affinity nerve growth factor receptor (NGF R), also named p75 neurotrophin receptor, is a type I transmembrane protein that belongs to the tumor necrosis factor (TNF) receptor superfamily and has been designated TNFRSF16. NGF R binds the neurotrophins NGF, BDNF, NT-3 and NT-4. It also binds several myelin derived proteins (Nogo, myelin associated glycoprotein, and myelin oligodendrocyte glycoprotein) as a co-receptor with Nogo receptor.

This antibody has proven an excellent marker for Schwann Cells. (see for example: http://www.pnas.org/content/early/2013/01/30/1222729110.full.pdf).

Images

CFTR is functionally active in Schwann cells. (A) Primary cultures of porcine Schwann cells were used 4 wk after seeding when they had developed the specific bipolar morphology and a phase-bright cell body under differential interference contrast microscopy. Schwann cells were positive for the phenotypic markers S100 and p75. (B) Whole-cell current recorded in the presence of PKA and ATP in the pipette solution and 1 min after adding 100 μM of CFTR inhibitor GlyH-101 to the bath solution.

CFTR is functionally active in Schwann cells. (A) Primary cultures of porcine Schwann cells were used 4 wk after seeding when they had developed the specific bipolar morphology and a phase-bright cell body under differential interference contrast microscopy. Schwann cells were positive for the phenotypic markers S100 and p75. (B) Whole-cell current recorded in the presence of PKA and ATP in the pipette solution and 1 min after adding 100 μM of CFTR inhibitor GlyH-101 to the bath solution.