Product Details
Catalog Number: GT15059
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: Purified, NS0-derived, recombinant human Leptin R (rhLeptin R) extracellular domain.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Entrez: 3953
UniProt: P48357
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

Leptin is a product of the mouse obese gene. Mice with mutations in the obese gene that block the synthesis of leptin are obese and diabetic and have reduced activity, metabolism, and body temperature. Rat leptin shares approximately 96% and 82% sequence identity with the mouse and human protein, respectively. The expression of leptin mRNA is restricted to adipose tissue.

Leptin receptor (OB R), also named B219, is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and the LIF receptor. Multiple isoforms of human and mouse OB R, including a long form (OB RL) with a large cytoplasmic domain capable of signal-transduction, and several receptor isoforms with short cytoplasmic domains (OB RS) lacking signal transducing capabilities, have been identified.

Images
Leptin Receptor Staining of paraffin embedded tissue sections of human brain  with HRP-DAB  (brown) and Haematoxylin (blue).

Leptin Receptor Staining of paraffin embedded tissue sections of human brain with HRP-DAB (brown) and Haematoxylin (blue).

Leptin Receptor Staining of paraffin embedded tissue sections of human brain  with HRP-DAB  (brown) and Haematoxylin (blue).

Leptin Receptor Staining of paraffin embedded tissue sections of human brain with HRP-DAB (brown) and Haematoxylin (blue).