PDGF isoforms exert their cellular effect by binding to the structurally similar receptor tyrosine kinases (RTKs), PDGF R alpha and PDGF R beta. PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD and PDGF-AB isofoms bind the two distinct cell surface PDGF receptors with different affinities. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of receptor tyrosine kinases (RTK). All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo-and heterodimerization leading to signal transduction. The expression of alpha and beta receptors are independently regulated in various cell types.
PDGF has also been linked to atherosclerosis, fibrosis and malignant diseases.
- Product ReviewsI ordered PDGFRb antibody (GT15065)sep 26th and received the product the next day. The antibody worked well for immunocytochemistry on mouse brain sections.Gulnaz Begum - Oct 13, 2017 - Rating: 5.0
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