Product Details
Catalog Number: GT15065
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: Recombinant mouse PDGF Receptor beta extracellular domain
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

PDGF isoforms exert their cellular effect by binding to the structurally similar receptor tyrosine kinases (RTKs), PDGF R alpha and PDGF R beta. PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD and PDGF-AB isofoms bind the two distinct cell surface PDGF receptors with different affinities. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of receptor tyrosine kinases (RTK). All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo-and heterodimerization leading to signal transduction. The expression of alpha and beta receptors are independently regulated in various cell types.

 PDGF has also been linked to atherosclerosis, fibrosis and malignant diseases.  

Images
Detection of PDGF Receptor in cryostat tissue sections of mouse embryo (spinal cord).

Detection of PDGF Receptor in cryostat tissue sections of mouse embryo (spinal cord).

Detection of PDGF Receptor in cryostat tissue sections of mouse embryo (spinal cord).

Detection of PDGF Receptor in cryostat tissue sections of mouse embryo (spinal cord).