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PDGF isoforms exert their cellular effect by binding to the structurally similar receptor tyrosine kinases (RTKs), PDGF R alpha and PDGF R beta. PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD and PDGF-AB isofoms bind the two distinct cell surface PDGF receptors with different affinities. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of receptor tyrosine kinases (RTK). All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo-and heterodimerization leading to signal transduction. The expression of alpha and beta receptors are independently regulated in various cell types.
PDGF has also been linked to atherosclerosis, fibrosis and malignant diseases.
- Product ReviewsExcellent service, prompt. Product Name: PDGF R BETA/CD140B, goat - (Cat# GT15065) https://www.neuromics.com/GT15065 Organization: University of Texas McGovern Med SchoolLori - Jan 19, 2018 - Rating: 5.0I ordered PDGFRb antibody (GT15065)sep 26th and received the product the next day. The antibody worked well for immunocytochemistry on mouse brain sections.Gulnaz Begum - Oct 13, 2017 - Rating: 5.0
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- Product Publications
- N Shioda, Y Yabuki, Y Wang, M Uchigashima, T Hikida, T Sasaoka, H Mori, M Watanabe, M Sasahara and K Fukunaga. (2016). Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons. Molecular Psychiatry, doi: 10.1038/mp.2016.200
- Christoph M. Zehendner, Anne Sebastiani, André Hugonnet, Florian Bischoff, Heiko J. Luhmann & Serge C. Thal. (2015). Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex. Scientific Reports 5, Article number: 13497 (2015) doi: 10.1038/srep13497
- Jie Shen, Yoko Ishii, Guihua Xu, Thanh Chung Dang, Takeru Hamashima, Takako Matsushima, Seiji Yamamoto, Yuichi Hattori, Yusuke Takatsuru, Junichi Nabekura and Masakiyo Sasahara. (2011). PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism, doi: 10.1038/jcbfm.2011.136
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