Endostatin (20-22 kDa), a cleaved product of the C-terminal domain of collagen XVIII, is an endogenous angiogenesis inhibitor. Endostatin inhibits endothelial cell migration (in vivo and in vitro) and induces endothelial cell apoptosis.
Endostatin eliminated tumors in mice. Researchers reported that the proteins eliminated forms of colon, prostate, breast and brain cancers in the animal experiments. Endostatin also appears to block new blood vessel growth in tumors blocking the metastatic process.
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