Product Details
Catalog Number: GT15080
Applications: WB, IHC, E
Type: Goat IgG
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse, Rat
Entrez: 4915
UniProt: Q16620
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

The biological activities of the neurotrophins are mediated by binding to the different members of the Trk family tyrosine kinase receptors. Three Trk family proteins, TrkA, TrkB and TrkC, exhibiting different ligand specificities, have been identified. At the protein sequence level, Trks are highly conserved between species and the proteins exhibit cross-species activity.

Images

TrkB staining of perfusion fixed frozen sections mouse spinal cord (dilution:1.7 μg/mL) Tissue was stained with 557 conjugated AntiGoat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to neuronal processes and cell bodies.

TrkB staining of perfusion fixed frozen sections mouse spinal cord (dilution:1.7 μg/mL) Tissue was stained with 557 conjugated AntiGoat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to neuronal processes and cell bodies.

Vagal nerve stimulation (VNS) rapidly induces TrkB activation in rat hippocampus. Effects of acute (2 hr) VNS, desipramine (DMI, 10 mg/kg, i.p) or fluoxetine (15 mg/kg, i.p) on TrkB phosphorylation at different tyrosine residues in rat hippocampus.Phospho-TrkB values are normalized against total-TrkB values. One-way MANOVA, Student's Newman-Keuls post-hoc test, *P<0.05, n=4−8 per group. doi:10.1371/journal.pone.0034844.

Vagal nerve stimulation (VNS) rapidly induces TrkB activation in rat hippocampus. Effects of acute (2 hr) VNS, desipramine (DMI, 10 mg/kg, i.p) or fluoxetine (15 mg/kg, i.p) on TrkB phosphorylation at different tyrosine residues in rat hippocampus.Phospho-TrkB values are normalized against total-TrkB values. One-way MANOVA, Student's Newman-Keuls post-hoc test, *P<0.05, n=4−8 per group. doi:10.1371/journal.pone.0034844.