GFRα-4 is a member of a family of at least four cysteine-rich GPI-linked cell surface proteins that function as ligand binding subunits for the GDNF family (GDNF, neurturin, persephin and artemin). A functional receptor complex is achieved through association with the c-Ret receptor tyrosine kinase. GFRα-4 preferentially binds persephin.
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