Product Details
Catalog Number: GT15111
Applications: WB, IHC
Type: Goat IgG
Dilutions: Western Blot: 1 ug/ml; Immunohistochemistry: 5-15 ug/ml
Immunogen: Recombinant human extracellular signal-regulated kinase-2
Storage: The antibody can be stored at 2° - 8° C for 1 month without detectable loss of activity. Antibody can also be aliquotted and stored frozen at -20° C to -70° C in a manual defrost freezer for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 5594
UniProt: P28482
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ug$345.00Add to Cart

ERK1 and ERK2 (also known as MAPK3 and MAPK1) are 44- and 42-kDa Ser/Thr kinases, respectively. They are part of the Ras-Raf-ERK signal transduction cascade often found downstream of growth factor receptor activation. ERK1 and ERK2 were initially isolated and cloned as kinases activated in response to insulin and NGF. They are expressed in most, if not all, mammalian tissues. Dual threonine and tyrosine phosphorylation activate both ERKs, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2.

ERK2 is involved in various cellular proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals making it useful for the study of processes like angiogenesis, neurogenesis and tumorigenesis. The activation of ERK by proinflammatory stimuli may play important roles in innate immune responses and autoimmunity.

Images
Detection of ERK2 with GT15111.  Immunoblot  of lysates from human HeLa and U937 cells and mouse TS1 and NIH/3T3 cells using anti-ERK2 antibody.

Detection of ERK2 with GT15111. Immunoblot of lysates from human HeLa and U937 cells and mouse TS1 and NIH/3T3 cells using anti-ERK2 antibody.

Detection of ERK2 with GT15111.  Immunoblot  of lysates from human HeLa and U937 cells and mouse TS1 and NIH/3T3 cells using anti-ERK2 antibody.

Detection of ERK2 with GT15111. Immunoblot of lysates from human HeLa and U937 cells and mouse TS1 and NIH/3T3 cells using anti-ERK2 antibody.