BACEs (Beta-site APP-Cleaving Enzymes), also named β-secretases, are membrane-bound aspartic proteases of the pepsin family. BACE-1 is the principle beta-secretase responsible for cleavage of amyloid precursor protein (APP) and, therefore, is a potential target for treatment of Alzheimer's disease. BACE-1 is widely expressed and likely has additional functions including the liberation of a membrane-bound sialyltransferase.
It is important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells.
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Name Catalog # Size BACE1 RA21010 50 ug GABA A receptor alpha 4 GT41008 100 ug GABA A Receptor beta 3 GT41011 100 ug GABA A receptor, pi subunit RA30047 50 ug GABA Receptor Associated Protein RA19014 100 ug GluR2/AMPA2 RA30012 50 ug GluR4/AMPA4 GT41012 100 ug Nicotinic acetylcholine receptor alpha7 GT41009 100 ug NMDA NR1 Pan MO25041 15 ug NMDA Receptor 1, N1 RA25036 25 ug NMDA Receptor 2A RA25037 100 ul NMDA Receptor 2B RA25063 10 ug P2X1 RA10107 150 ul P2X1 RA10107 50 ul P2X2 GP14106 150 ul P2X2 GP14106 50 ul P2X2 RA10108 150 ul P2X2 RA10108 50 ul P2X3 GP10108 100 ul P2X3 RA10109 150 ul P2X3 RA10109 50 ul P2X3-Pure RA14139 100 ul p504s/AMACR (α-Methylacyl Coenzyme A Racemase) MO47014 100 ul phospho-NMDA Receptor 1 (Ser890) RA18011 100 ul Phospho-NMDA Receptor 1 (Ser896) RA18012 100 ul PSAP (Prostatic Specific Acid Phosphatase)/PAP MO47053 100 ul S-100 MO47059 100 ul