GAD1, also named 67 kDa or brain GAD, is an enzyme that catalyzes the formation of the inhibitory neurotransmitter γ-amino butyric acid (GABA) from glutamate. GAD1 is also expressed in multiple non-neuronal tissues during development.
A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures.
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- Maria J. Barnes, Richard C. Rogers, Montina J. Van Meter and Gerlinda E. Hermann. (2010). Co-localization of TRHR1 and LepRb receptors on neurons in the hindbrain of the rat. Brain Research, doi: 10.1016/j.brainres.2010.07.094
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