Product Details
Catalog Number: GT15142
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: E. coli-derived, recombinant human Glutamate Decarboxylase 1 (rhGAD1; aa 2 - 97).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 2571
UniProt: Q99259
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

GAD1, also named 67 kDa or brain GAD, is an enzyme that catalyzes the formation of the inhibitory neurotransmitter γ-amino butyric acid (GABA) from glutamate. GAD1 is also expressed in multiple non-neuronal tissues during development.

A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures.  

Images
GAD1 staining of inhibitory neurons in the mouse cortex. Neurons were stained with  antigoat alexafluor 568 secondary from invitrogen(red) and a dapi counterstain (blue). Courtesy of Dr. Aaron Hirko, University of Pittsburgh.

GAD1 staining of inhibitory neurons in the mouse cortex. Neurons were stained with antigoat alexafluor 568 secondary from invitrogen(red) and a dapi counterstain (blue). Courtesy of Dr. Aaron Hirko, University of Pittsburgh.

GAD1 staining of inhibitory neurons in the mouse cortex. Neurons were stained with  antigoat alexafluor 568 secondary from invitrogen(red) and a dapi counterstain (blue). Courtesy of Dr. Aaron Hirko, University of Pittsburgh.

GAD1 staining of inhibitory neurons in the mouse cortex. Neurons were stained with antigoat alexafluor 568 secondary from invitrogen(red) and a dapi counterstain (blue). Courtesy of Dr. Aaron Hirko, University of Pittsburgh.

Detection of GAD1/GAD67 in paraffin-embedded human cerebellum tissue sections at a dilution of 15 µg/mL. Tissues were stained with anti-goat HRP-DAB (brown) and counterstained with hematoxylin (blue).

Detection of GAD1/GAD67 in paraffin-embedded human cerebellum tissue sections at a dilution of 15 µg/mL. Tissues were stained with anti-goat HRP-DAB (brown) and counterstained with hematoxylin (blue).

Detection of GAD1/GAD67 in paraffin-embedded human cerebellum tissue sections at a dilution of 15 µg/mL. Tissues were stained with anti-goat HRP-DAB (brown) and counterstained with hematoxylin (blue).

Detection of GAD1/GAD67 in paraffin-embedded human cerebellum tissue sections at a dilution of 15 µg/mL. Tissues were stained with anti-goat HRP-DAB (brown) and counterstained with hematoxylin (blue).