PDGF isoforms exert their cellular effect by binding to the structurally similar receptor tyrosine kinases (RTKs), PDGF R alpha and PDGF R beta. PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD and PDGF-AB isofoms bind the two distinct cell surface PDGF receptors with different affinities. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of receptor tyrosine kinases (RTK). All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo-and heterodimerization leading to signal transduction. The expression of alpha and beta receptors are independently regulated in various cell types.
PDGF has also been linked to atherosclerosis, fibrosis and malignant diseases.
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- Product Publications
- Laura Thomas, Laura Andrea Pasquini (2019). Galectin-3 Exerts a Pro-differentiating and Pro-myelinating Effect Within a Temporal Window Spanning Precursors and Pre-oligodendrocytes: Insights into the Mechanisms of Action. L.A. Mol Neurobiol. https://doi.org/10.1007/s12035-019-01787-3
- Vigo María Belén, Pérez María Julia, De Fino Fernanda, Gómez Gimena, Martínez Sonia A, Bisagno Veronica, Di Carlo María Beatriz, Scazziota Alejandra, Manautou José E, Ghanem Carolina I. (2019). Acute Acetaminophen Intoxication Induces Direct Neurotoxicity in Rats Manifested as Astrogliosis and Decreased Dopaminergic Markers in Brain Areas Associated With Locomotor Regulation. Biochemical Pharmacology. https://doi.org/10.1016/j.bcp.2019.113662
- Thành ChungĐặng, Yoko Ishii, Van De Nguyen, Seiji Yamamoto, Takeru Hamashima, Noriko Okuno, Quang Linh Nguyen, Yang Sang, Noriaki Ohkawa, Yoshito Saitoh, Mohammad Shehata, Nobuyuki Takakura, Toshihiko Fujimori, Kaoru Inokuchi, Hisashi Mori, Johanna Andrae, Christer Betsholtz, Masakiyo Sasahara. (2019). Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRα in Adult Brain. Cell Reports. Volume 27, Issue 4, Pages 1073-1089.e5. https://doi.org/10.1016/j.celrep.2019.03.084
- Victoria Sofía Berenice Wies Mancini Juana María Pasquini Jorge Daniel Correale Laura Andrea Pasquini (2018). Microglial modulation through colony‐stimulating factor‐1 receptor inhibition attenuates demyelination. Glia. https://doi.org/10.1002/glia.23540
- Laura Thomas and Laura Andrea Pasquini. (2018). Extracellular Galectin-3 Induces Accelerated Oligodendroglial Differentiation Through Changes in Signaling Pathways and Cytoskeleton Dynamics. Mol Neurobiol https://doi.org/10.1007/s12035-018-1089-6
- H. C. Hoyos, Mariel Marder, R. Ulrich, V. Gudi, M. Stangel, G. A. Rabinovich, L. A. Pasquini, J. M. Pasquini. (2016). The Role of Galectin-3: From Oligodendroglial Differentiation and Myelination to Demyelination and Remyelination Processes in a Cuprizone-Induced Demyelination Model. Advances in Experimental Medicine and Biology, Volume 949, pp 311-332. doi: 10.1007/978-3-319-40764-7_15
- Rinaldi M., Thomas L.a, Mathieu P., Carabias P., Troncoso M.F., Pasquini J.M., Rabinovich G.A., Pasquini L.A. (2016). Galectin-1 circumvents lysolecithin-induced demyelination through the modulation of microglial polarization/phagocytosis and oligodendroglial differentiation. Neurobiology of Disease, Volume 96, December 2016, Pages 127-143. doi: 10.1016/j.nbd.2016.09.003
- Yang Zheng, Seiji Yamamoto, Yoko Ishii, Yang Sang, Takeru Hamashima, Nguyen Van De, Hirofumi Nishizono, Ran Inoue, Hisashi Mori, and Masakiyo Sasahara. (2015). Glioma-Derived Platelet-Derived Growth Factor-BB Recruits Oligodendrocyte Progenitor Cells via Platelet-Derived Growth Factor Receptor-α and Remodels Cancer Stroma. The American Journal of Pathology, doi: 10.1016/j.ajpath.2015.12.020
- Paula G. Franco, Juana M. Pasquini, Lucas Silvestroff. (2015). Optimizing Culture Medium Composition to Improve Oligodendrocyte Progenitor Cell Yields In Vitro from Subventricular Zone-Derived Neural Progenitor Cell Neurospheres. PLoS ONE, doi: 10.1371/journal.pone.0121774
- María Julia Pérez, Natalia Fernandez, Juana María Pasquini. (2013). Oligodendrocyte differentiation and signaling after transferrin internalization: A mechanism of action. Experimental Neurology, Volume 248, October 2013, Pages 262–274. doi: 10.1016/j.expneurol.2013.06.014
- Diego C. Fernandez, Laura A. Pasquini, Damián Dorfman, Hernán J. Aldana Marcos, Ruth E. Rosenstein. (2012). Ischemic Conditioning Protects from Axoglial Alterations of the Optic Pathway Induced by Experimental Diabetes in Rats. PLOS ONE, doi: 10.1371/journal.pone.0051966
- Diego C. Fernandez, Laura A. Pasquini, Damián Dorfman, Hernán J. Aldana Marcos, Ruth E. Rosenstein. (2012). Early Distal Axonopathy of the Visual Pathway in Experimental Diabetes. The American Journal of Pathology, doi: 10.1016/j.ajpath.2011.09.018
- L A Pasquini, V Millet, H C Hoyos, J P Giannoni, D O Croci, M Marder, F T Liu, G A Rabinovich and J M Pasquini. (2011). Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function. Cell Death & Differentiation, doi: 10.1038/cdd.2011.40
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