Product Details
Catalog Number: GT15150
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: NS0-derived, recombinant mouse plateletderived growth factor receptor alpha (rmPDGF R) extracellular domain.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse
Entrez: 5156
UniProt: P16234
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

PDGF isoforms exert their cellular effect by binding to the structurally similar receptor tyrosine kinases (RTKs), PDGF R alpha and PDGF R beta. PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD and PDGF-AB isofoms bind the two distinct cell surface PDGF receptors with different affinities. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of receptor tyrosine kinases (RTK). All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo-and heterodimerization leading to signal transduction. The expression of alpha and beta receptors are independently regulated in various cell types.

PDGF has also been linked to atherosclerosis, fibrosis and malignant diseases.  

PDGF R Alpha/CD140A Customer Publications-(for staining of Oligodendrocyte Lineage (OL) Cells see 10.1016/j.ajpath.2011.09.018.

Images
PDGF  Staining in Rα in cryostat tissue sections of mouse embryo (13 d.p.c.) using 15 µg/mL of PDGF R Alpha. Tissues were stained using HRP-DAB (red-brown) and counterstained with hematoxylin (blue).

PDGF Staining in Rα in cryostat tissue sections of mouse embryo (13 d.p.c.) using 15 µg/mL of PDGF R Alpha. Tissues were stained using HRP-DAB (red-brown) and counterstained with hematoxylin (blue).

PDGF  Staining in Rα in cryostat tissue sections of mouse embryo (13 d.p.c.) using 15 µg/mL of PDGF R Alpha. Tissues were stained using HRP-DAB (red-brown) and counterstained with hematoxylin (blue).

PDGF Staining in Rα in cryostat tissue sections of mouse embryo (13 d.p.c.) using 15 µg/mL of PDGF R Alpha. Tissues were stained using HRP-DAB (red-brown) and counterstained with hematoxylin (blue).