Platelet-derived growth factor (PDGF) is a family of disulfide-linked dimeric proteins, which act mainly on connective tissue. The PDGF family consists of four homodimeric proteins, PDGF-AA, PDGF-BB, PDGF-CC, and PDGF-DD, and one heterodimeric protein, PDGF-AB. The dimeric isoforms of PDGF are differentially expressed during embryonal development. The dimeric isoforms of PDGF are also differentially expressed in various cell types.
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- Kaja Skjefstada, Elin Richardsena, Tom Donnemc, Sigve Andersenc, Yury Kiseleva, Thea Grindstad, Sigurd M. Hald, Khalid Al-Shibli, f, Roy M. Bremnes, d, Lill-Tove Busunda, Samer Al-Saad. (2015), The prognostic role of progesterone receptor expression in non-small cell lung cancer patients: Gender-related impacts and correlation with disease-specific survival. Steroids, doi:10.1016/j.steroids.2015.01.020
- Thomas Karsten Kilvaer, Andrej Valkov, Sveinung W. Sorbye, Tom Donnem, Eivind Smeland, Roy Martin Bremnes,and Lill-Tove Busund. (2010). Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival. Sarcoma, doi: 10.1155/2010/751304
- T. Donnem, S. Al-Saad, K. Al-Shibli, L.-T. Busund and R. M. Bremnes. (2010). Co-expression of PDGF-B and VEGFR-3 strongly correlates with lymph node metastasis and poor survival in non-small-cell lung cancer. Annals of Oncology, 2010 21(2):223-231; doi: 10.1093/annonc/mdp296
- Donnem, Tom MD, Al-Saad, Samer MD, Al-Shibli, Khalid MD, Andersen, Sigve MD, Busund, Lill-Tove MD, PhD, Bremnes, Roy M. MD, PhD. (2008). Prognostic Impact of Platelet-Derived Growth Factors in Non-small Cell Lung Cancer Tumor and Stromal Cells. Journal of Thoracic Oncology, 3(9):963-970. doi: 10.1097/JTO.0b013e3181834f52
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