Product Details
Catalog Number: GT15172
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: Purified, E. coli-derived, recombinant human Hairy and Enhancer of Split-1 (rhHES-1; aa 93 - 280; Accession # Q14469).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 3280
UniProt: Q14469
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

HES-1 (Hairy and Enhancer of Split-1) is a transcriptional repressor that is a target of notch signaling. It contains a basic helix-loop-helix (bHLH) DNA-binding domain, an Orange domain and a C-terminal tetrapeptide WRPW motif that binds to the Groucho (Gro)/TLE/Grg family of corepressors. HES-1 can form both homo- and heterodimers with other HES family members. Dimerization is mediated through both the bHLH and the downstream Orange domain. Over the sequence used for immunization, human HES-1 shares 97% and 98% amino acid sequence identity with mouse and rat HES-1, respectively. Hes1 deficient embryos show severe defects in neuronal development, as well as pancreatic hypoplasia. It is believed to exert influence on the development of radial Glial Cells. HES-1 could play a role as a tumor suppressor in epithelial cells, and as a mediator of 17beta-estradiols have a role in proliferating breast cancer cells.

Images
HES-1 staining of  paraffin-embedded human ovarian cancer tissue. HRP-DAB reagents (brown color) were used for the detection. Tissue sections were counterstained using hematoxylin (blue).

HES-1 staining of paraffin-embedded human ovarian cancer tissue. HRP-DAB reagents (brown color) were used for the detection. Tissue sections were counterstained using hematoxylin (blue).

HES-1 staining of  paraffin-embedded human ovarian cancer tissue. HRP-DAB reagents (brown color) were used for the detection. Tissue sections were counterstained using hematoxylin (blue).

HES-1 staining of paraffin-embedded human ovarian cancer tissue. HRP-DAB reagents (brown color) were used for the detection. Tissue sections were counterstained using hematoxylin (blue).