HES-1 (Hairy and Enhancer of Split-1) is a transcriptional repressor that is a target of notch signaling. It contains a basic helix-loop-helix (bHLH) DNA-binding domain, an Orange domain and a C-terminal tetrapeptide WRPW motif that binds to the Groucho (Gro)/TLE/Grg family of corepressors. HES-1 can form both homo- and heterodimers with other HES family members. Dimerization is mediated through both the bHLH and the downstream Orange domain. Over the sequence used for immunization, human HES-1 shares 97% and 98% amino acid sequence identity with mouse and rat HES-1, respectively. Hes1 deficient embryos show severe defects in neuronal development, as well as pancreatic hypoplasia. It is believed to exert influence on the development of radial Glial Cells. HES-1 could play a role as a tumor suppressor in epithelial cells, and as a mediator of 17beta-estradiols have a role in proliferating breast cancer cells.
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- Angelo Iulianella, Madhulika Sharma, Greg B. Vanden Heuvel, and Paul A. Trainor. (2009). Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord. Development, 136, 2329-2334. doi: 10.1242/10.1242/dev.032128
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