The TGFp superfamily of ligands plays key functions in development and disease. In both human and mouse embryonic stem cells, a member of this family, GDF3, is specifically expressed in the pluripotent state. We show that GDF3 is an inhibitor of its own subfamily, blocks classic BMP signaling in multiple contexts, interacts with BMP proteins and is expressed specifically in the node during gastrulation in a pattern consistent with BMP inhibition. Furthermore, we use gain- and reduction-of-function to show that in a species-specific manner, GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell.
GDF-3 is suspected to be expressed in certain forms of cancer. These could include Breast and Testicular Cancer.
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Name Catalog # Size BMP-1/PCP GT15120 100 ug BMP-10 RA30003 50 ug BMP-2 Inducible Kinase (BIKE) RA30004 50 ug BMP-2/4 GT15053 100 ug BMP-3 MO15038 100 ug BMP-3 MO15038 50 ug BMP-3b/GDF-10 GT15166 100 ug BMP-4 RA30035 50 ug BMP-5 GT15054 100 ug BMP-6 GT15167 100 ug BMP-7 MO15079 100 ug BMP-7 MO15079 500 ug BMP-8 GT15161 100 ug Chordin GT15191 100 ug GDF-5 GT15177 100 ug GDF-8/Myostatin GT15213 100 ug GDF-9 GT15214 100 ug RUNX2 GT15188 100 ug