Platelet-Derived Endothelial Cell Growth Factor is also named thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is identified as an angiogenic factor.
PD-ECGF might contribute to the growth of uterine cervical and prostate cancer (via angiogenesis related to vascular spreading) and a variety of other malignancies.
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