Product Details
Catalog Number: GT15182
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: Purified, E. coli-derived, recombinant human insulin-like growth factor II (rhIGF-II).
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Downloads: Datasheet (pdf)
Product Sizes
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250 ug$365.00Add to Cart

Insulin-like growth factor I (also known as somatomedin C and somatomedin A) and insulin-like growth factor II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved (100% identity between human, bovine and porcine proteins) and exhibit cross-species activity. IGF-II is a potent mitogenic growth factor.

IGF-II binding is significantly increased in the diabetic kidney and could play a role in diabetic neuropathy. It also appears to be involved significantly in the progression of many tumors

Images
IGF-II staining ofParaffin-embedded tissue sections of human placenta (chorionic villi). Tissue was  HRP-AEC Cell  (red) and counter stained with Haematoxylin (blue).

IGF-II staining ofParaffin-embedded tissue sections of human placenta (chorionic villi). Tissue was HRP-AEC Cell (red) and counter stained with Haematoxylin (blue).

IGF-II staining ofParaffin-embedded tissue sections of human placenta (chorionic villi). Tissue was  HRP-AEC Cell  (red) and counter stained with Haematoxylin (blue).

IGF-II staining ofParaffin-embedded tissue sections of human placenta (chorionic villi). Tissue was HRP-AEC Cell (red) and counter stained with Haematoxylin (blue).