Runt-related transcription factor 2 (RUNX2), also know as CBFA1, is a 56 kDa DNA-binding protein that belongs to the Runt-related family of transcription factors. It is synthesized as a 521 amino acid (aa) protein with multiple domains. From the N-terminus, there is a 19 aa activation domain (AD1), a 41 aa glutamine/alanine (Q/A) repeat segment (AD2), a 128 aa Runt/DNA-binding region, a 9 aa NLS and a 285 aa ProSerThr (PST)-rich sequence that is needed for gene activation. Two isoforms exist, one with a truncated AD1 domain and another with a 22 aa deletion in the AD3 section of PST-rich sequence. Human CBFA1 is 98% aa identical to mouse CBFA1.
RUNX2 is marker for Mesenchymal Stem Cells/Osteoblast Differentiation.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size BMP-1/PCP GT15120 100 ug BMP-10 RA30003 50 ug BMP-2 Inducible Kinase (BIKE) RA30004 50 ug BMP-2/4 GT15053 100 ug BMP-3 MO15038 500 ug BMP-3b/GDF-10 GT15166 100 ug BMP-4 MO15134 100 ug BMP-4 RA30035 50 ug BMP-5 GT15054 100 ug BMP-6 GT15167 100 ug BMP-7 MO15079 100 ug BMP-7 MO15079 500 ug BMP-8 GT15161 100 ug Chordin GT15191 100 ug Chordin-Like 2/CHRDL2 MO15143 100 ug GDF-3 GT15176 100 ug GDF-5 GT15177 100 ug GDF-8/Myostatin GT15213 100 ug GDF-9 GT15214 100 ug