Chordin is an extracellular antagonist of BMP signaling which is thought to readily diffuse in tissues, thus forming gradients of BMP inhibition that result in reciprocal gradients of BMP signaling thus impacting cell fate determination along the embryonic dorsoventral axis.
This antibody will block > 95% of the binding of 100 ng/mL of rhBMP-4 to immobilized rmChordin. (100 μL of 5 g/mL was coated in each well) in a functional ELISA. 50% inhibition occurs at an antibody concentration of approximately 3 - 12 μg/mL.
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Name Catalog # Size BMP-1/PCP GT15120 100 ug BMP-10 RA30003 50 ug BMP-2 Inducible Kinase (BIKE) RA30004 50 ug BMP-2/4 GT15053 100 ug BMP-3 MO15038 500 ug BMP-3b/GDF-10 GT15166 100 ug BMP-4 MO15134 100 ug BMP-4 RA30035 50 ug BMP-5 GT15054 100 ug BMP-6 GT15167 100 ug BMP-7 MO15079 100 ug BMP-7 MO15079 500 ug BMP-8 GT15161 100 ug Chordin-Like 2/CHRDL2 MO15143 100 ug GDF-3 GT15176 100 ug GDF-5 GT15177 100 ug GDF-8/Myostatin GT15213 100 ug GDF-9 GT15214 100 ug RUNX2 GT15188 100 ug