Product Details
Catalog Number: GT15192
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: Purified, E. coli-derived, recombinant human Mothers against DPP homolog 5 (rhSmad5; aa 155 - 258).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 4090
UniProt: Q99717
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

SMAD5 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, eight SMADs have been identified and can be divided into 3 subgroups based on their structure and function; pathway-restricted, common mediator and inhibitory. SMAD1, 5 and 8 serve as pathway-restricted SMADs for the bone morphogenetic protein (BMP) signaling pathway. SMAD5 is directly activated by BMP type Ia or Ib receptors upon BMP-2 stimulation and transduced BMP-2 signals to the nucleus by forming a complex with SMAD4.

Smad5 could be a marker for several forms of cancer inluding colo-rectal.

Images
SMAD5 staining paraffin-embedded human colon tissue sections (dilution  5 µg/mL). Tissues were stained usiing anti-goat HRP-DAB (brown) and counterstained with hematoxylin (blue).

SMAD5 staining paraffin-embedded human colon tissue sections (dilution 5 µg/mL). Tissues were stained usiing anti-goat HRP-DAB (brown) and counterstained with hematoxylin (blue).

SMAD5 staining paraffin-embedded human colon tissue sections (dilution  5 µg/mL). Tissues were stained usiing anti-goat HRP-DAB (brown) and counterstained with hematoxylin (blue).

SMAD5 staining paraffin-embedded human colon tissue sections (dilution 5 µg/mL). Tissues were stained usiing anti-goat HRP-DAB (brown) and counterstained with hematoxylin (blue).