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The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate.
SOX9 belongs to the SOX (SRY-like HMG box) family of transcription factors with diverse roles in development. SOX9 is expressed in mesenchymal progenitors that give rise to chondrocytes and osteoblasts. It is also expressed in the central nervous system, neural crest, intestine, pancreas and testis. Mutations in SOX9 are associated with defects in sex determination, cartilage and bone development, as well as abnormalities of the heart, kidneys, brain, gut and pancreas.
Note: This antibody has been selected for its ability to recognize human SOX9 in IHC, direct ELISAs and western blots, this antibody shows approximately 10% cross-reactivity with rhSOX10 and less than 5% cross-reactivity with rhSOX2, rhSOX3, rhSOX7 and rhSOX17.