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The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate.
SOX21 is a member of the B group of the SOX family HMG-box transcription factors. It is a 276 amino acid residue protein that has an N-terminal HMG-box and a C-terminal domain that is required for the SOX21 neurogenesis function. Human and mouse SOX 21 share 99% amino acid sequence identity.
Note: This antibody has been selected for its ability to recognize human SOX21 in IHC, direct ELISAs and western blots. In direct ELISAs and western blots, this antibody shows less than 1% cross-reactivity with rhSOX1, rhSOX2 and rhSOX15.
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- Maria Ferletta,Demet Caglayan ,Liza Mokvist, Yiwen Jiang, Marianne Kastemar, Lene Uhrbom and Bengt Westermark. (2010). Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells. International Journal of Cancer, doi: 10.1002/ijc.25647
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