Product Details
Catalog Number: GT15211
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: Produced in goats immunized with purified, E. coli-derived, recombinant mouse Plexin A3 (rmPlexin A3; aa 34 - 150; Accession # P70208).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 55558
UniProt: P51805
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

Plexin A3 (also known as SEX) is a 220 kDa member of the Plexin A subfamily of semaphorin receptors. Mature mouse Plexin A3 is predicted to be an 1853 amino acid (aa) type I transmembrane glycoprotein that contains a 1202 aa extracellular domain (ECD) and a 629 aa cytoplasmic region. The ECD contains one semaphorin domain (aa # 34 - 473), three plexin-semaphorin-integrin (PSI) domains (aa # 492 - 830), and four lg-like plexin-transcription factor (IPT) repeats (aa # 841 - 1209). Plexin A3 interacts with neuropilins 1 and 2, and binds class 3 semaphorins. Over aa # 35 - 150, mouse Plexin A3 is 99% and 97% aa identical to rat and human Plexin A3, respectively.

Plexin A3 is involved in the development of neural and epithelial tissues.

Images

Detection of Plexin A3 in mouse embryonic (E13.5) spinal cord. Cells were stained using NorthernLightsTM 577 fluorochrome labeled secondary antibody (red) and counterstained with DAPI (blue).

Detection of Plexin A3 in mouse embryonic (E13.5) spinal cord. Cells were stained using NorthernLightsTM 577 fluorochrome labeled secondary antibody (red) and counterstained with DAPI (blue).