PTCH2 (Patched Family) is a 1203-aa transmembrane protein. It is a possible sonic hedgehog receptor, highly similar to PTCH and containing an SSD domain, that may have a role formation of embryonic structures and in epidermal development. The Drosophila patched-hedgehog signaling pathway establishes segment polarity and anterior-posterior orientation. The patched pathway is conserved from fly to vertebrates. With 56% identity to Patched-1, mouse Patched-2 diverges in the hydrophilic region between transmembrane domains 6 and 7 and in a region of the intracellular C terminus. (NCI)
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