FAS Ligand, also known as CD95L or APT1LG1 , is a member of the TNF receptor family.
The full length Fas-L protein has a cytoplasmic domain, transmembrane (Type II) domain and extracellular domain. The membrane-bound form of Fas-L is proteolytically cleaved to produce soluble Fas-L. There are at least 2 known isoforms of Fas-L produced by alternate splicing.
Fas ligand-receptor interactions play an important role in the regulation of the immune system and the progression of cancer.
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