The Vesicle Associated Membrane Proteins (VAMP) or synaptobrevins are calcium binding proteins. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered.
Human VAMP-1 is 118 amino acids (aa) in length. It is a type IV transmembrane protein that contains an N-terminal cytoplasmic region (aa 1 - 96) and a 22 aa transmembrane domain (aa 97 - 118). There is one coiled-coil region between aa 33 - 93. Multiple splice variants are known that show two, three, four and 81 aa substitutions for the C-terminal five amino acids. One three aa variant creates a mitochondrial targeting motif. Over aa 1 - 96, human VAMP-1 is 98% aa identical to mouse VAMP-1.
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Name Catalog # Size Bradykinin Receptor B2 RA14137 100 ul CADM1/SynCAM RA25084 100 ul Calbindin CH22118 100 ul Calbindin MO20016 100 ug Calbindin D MO15097 100 ug Calcineurin A MO15055 100 ug Calreticulin MO22164 100 ul Calretinin CH22116 100 ul Calretinin MO20024 100 ul Calretinin MO22166 100 ul Calretinin (IgG1) MO22165 100 ul CaMKII RA18006 100 ul CaMKII2A GT41019 100 ug Cav1.2 Ca2+ channel MO50006 100 ul Cav1.3 Ca2+ channel MO50007 100 ul Cav3.1 Ca2+ channel MO50008 100 ul EpCAM (Epithelial Cell Adhesion Molecule)/Epithelial Specific Antigen MO47063 100 ul MARCKS (Myristoylated Alanine Rich C Kinase Substrate) RA22111 100 ul Neurogranin precursor GT41024 100 ug phospho-Synapsin (Ser9) RA18009 100 ul S-100 MO47059 100 ul S100B GT15160 100 ug SHANK1a C-terminus RA19016 100 ug SHANK1a N-Terminus RA19015 100 ug Striatin RA25067 100 ul Synapsin RA18010 100 ul Synaptotagmin 1 MO15099 100 ug