Brg1, also known as ATP-dependent helicase SMARCA4, is a member of the SNF2 helicase family of molecules. It may facilitate and inhibit gene transcription. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Brg1 works to activate or repress transcription. It is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells
It is also thought to be crucial to the development of sperm and smooth muscle in the gastrointestinal tract.
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