Product Details
Catalog Number: GT15247
Applications: ICC, WB, IHC, FC
Type: Goat IgG
Immunogen: Mouse myeloma cell line NS0-derived recombinant human Endoglin. Glu26-Gly256 Accession Number Q5T9B9
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: lyophilized
Species Reactivity: Human
Entrez: 2022
UniProt: P17813
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

Endoglin (ENG), also known as CD105, is a type I integral transmembrane glycoprotein and is an accessory receptor for TGF-beta superfamily ligands. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages.

The role of endoglin in cancer can be contradicting at times since it is needed for neoangiogenesis in tumors, which is needed for tumor growth and survival, yet the reduction in expression of endoglin has in many cancers correlated with a negative outcome of that cancer.

Images

Endoglin/CD105 was detected in immersion fixed U937 human histiocytic lymphoma cell line using Goat Anti-Human Endoglin/CD105 Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # GT15247) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the 557‑conjugated Streptavidin and counterstained with DAPI (blue)

Endoglin/CD105 was detected in immersion fixed U937 human histiocytic lymphoma cell line using Goat Anti-Human Endoglin/CD105 Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # GT15247) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the 557‑conjugated Streptavidin and counterstained with DAPI (blue)

Endoglin/CD105 was detected in immersion fixed paraffin-embedded sections of human prostate array using Goat Anti-Human Endoglin/CD105 Biotinylated Antigen Affinity-purified Antibody (Catalog # GT15247) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP and counterstained with hematoxylin (blue).

Endoglin/CD105 was detected in immersion fixed paraffin-embedded sections of human prostate array using Goat Anti-Human Endoglin/CD105 Biotinylated Antigen Affinity-purified Antibody (Catalog # GT15247) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP and counterstained with hematoxylin (blue).