EX-527

EX-527 is a SIRT1 inhibitor (IC50=98 nM). However, it does not inhibit other HDACs or SIRT family members. It also increases p53 acetylation following DNA damage.

References:

1) J.M. Solomon, et al. (2006), Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage; Mol. Cell Biol.; 26 :28

2) J.L. Anderson et al. (2011) Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage; Mol. Cell, 43:834