EX-527 is a SIRT1 inhibitor (IC50=98 nM). However, it does not inhibit other HDACs or SIRT family members. It also increases p53 acetylation following DNA damage.
1) J.M. Solomon, et al. (2006), Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage; Mol. Cell Biol.; 26 :28
2) J.L. Anderson et al. (2011) Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage; Mol. Cell, 43:834
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