CD95, also known as FAS or APO1, is a 36 kDa cell surface type I membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS PAGE. CD95 is a member of the TNF receptor family, which includes TNFR1, TNFR2, CD27, CD30 and CD40. Binding of CD95 Ligand to CD95 or crosslinking of CD95 by anti CD95 monoclonal antibodies leads to apoptosis of CD95 expressing cells. CD95 belongs to a subgroup of family members that have a death domain (DD) which contains 70 amino acids near the carboxyl terminal region of the molecule. The binding of adaptor molecules to this DD is responsible for transmitting the death signal for Apoptosis.
Stimulation of CD95 results in aggregation of its DD, leading to the recruitment of FADD and caspase 8 that together with the receptor form the death inducing signaling complex (DISC). CD95 and its ligand CD95L are involved in the peripheral deletion of activated mature T cells at the end of the immune response and defects in this pathway predispose to autoimmune disorders. CD95 is also involved in killing of targets such as virus infected cells or cancer cells and killing of inflammatory cells at immune privileged sites.
- Product Reviews
- Related Products
Name Catalog # ACE/CD143 FC15000 ACE/CD143 GT15145 c-Kit/CD117 RA14132 CCR1/CD191 MO15088 CD11b (OX-42) CH23021 CD1a (Clone MT1B) MO20005 CD31/PECAM-1 GT15190 CD34/HPCA1 MO18004 CD34/HPCA1 MO20026 CD36 RA25035 CD39 GP10103 CD43 (Clone MT1) MO20006 CD44 Variant 3 MO20007 CD45 FC15008 CD45 MO18005 CD4 MO20025 CD9/Motility-Related Protein-1 MO20046 CDCP1/CD318 GT15233 CEACAM-1/CD66a MO15123 Endoglin/CD105 Fluorescein FC15022 Endoglin/CD105 GT15247 Endoglin/CD105 MO15124 FAS Ligand (CD95L) GT15226 FAS Ligand (CD95L) RA30043 Frizzled 4/CD344 GT15217 Galectin-3 (LGAS3) MO22119 gp130/CD 130 GT15072 gp130/CD130-Phycoerythrin Labeled FC15014 gp130/CD130 MO15024 IGF-I R/CD221-Fluorescein Labeled FC15010 IGF-I R/CD221 MO15074 IGF-II/C11orf43 GT15182 IL-2 R alpha/CD35 MO15070 Macrophage Scavenger Receptor I/CD204 RA25074 Neprilysin/CD10 MO15015 PDGF R Alpha/CD140A GT15150 PDGF R Beta/CD140B GT15065 Prion Protein/CD230 CH23027 TIE2 GT15148 TLR2/CD282 GT15234 TLR3/CD283 MO15121 TLR4/CD284 GT15235 TLR6/CD286 RA30053 TLR9/CD289 RA25070 TRAIL R1/CD261 GT15061 TRAIL R3/CD263 GT15062 TRAIL R4/CD264 GT15063