The human tissue kallikrein gene family contains 15 members that play important roles in cancer. Notably, KLK1, also known as tissue kallikrein, cleaves kininogen to release the vasoactive kinin peptide, bradykinin or lysyl-bradykinin. KLK3, called prostate specific antigen (PSA), is an established tumor marker that aids in the diagnosis, staging, and follow up of prostate cancer. KLK4 is specifically expressed in the prostate and overexpressed in prostate cancer. KLK5 is widely expressed but found at high levels in skin, breast, brain and testis; overexpression is an indicator of poor prognosis in ovarian cancer. KLK8 is expressed in the brain and is a novel marker of ovarian and cervical cancer.
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Name Catalog # Size Aurora A kinase MO22137 100 ul Aurora A/B/C kinase MO22139 100 ul Aurora B kinase MO22138 100 ul Kallikrein 10 GT15096 100 ug Kallikrein 11 GT15082 100 ug Kallikrein 11 MO15030 100 ug Kallikrein 5/KLK5/KLKL2 RA19046 100 ug Kallikrein 6/KLK6/Neurosin GT15097 100 ug Kallikrein 8/KLK8/Neuropsin MO15032 100 ug Kallikrein 8/KLK8/Neuropsin MO15032 500 ug KLK-3 (PSA) RA19044 100 ug KLK-L1 RA19045 100 ug KLK-L3 (KLK9) RA19047 100 ug KLK-L4 RA19048 100 ug KLK12 RA19049 100 ug KLK14 RA19050 100 ug KLK15 RA19051 100 ug