Product Details
Catalog Number: MO15030
Applications: WB, IHC, E
Type: Mouse IgG
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human
Entrez: 11012
UniProt: Q9UBX7
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ug$205.00$89.00Add to Cart

The human tissue kallikrein gene family contains 15 members that play important roles in cancer. Notably, KLK1, also known as tissue kallikrein, cleaves kininogen to release the vasoactive kinin peptide, bradykinin or lysyl-bradykinin. KLK3, called prostate specific antigen (PSA), is an established tumor marker that aids in the diagnosis, staging, and follow up of prostate cancer. KLK4 is specifically expressed in the prostate and overexpressed in prostate cancer. KLK5 is widely expressed but found at high levels in skin, breast, brain, and testis; overexpression is an indicator of poor prognosis in ovarian cancer. KLK8 is expressed in the brain and is a novel marker of ovarian and cervical cancer.

Images
Kallikrein 11 staining of paraffin-embedded human breast cancer tissue sections using 8 µg/mL of antibody. Tissues were stained with HRP-DAB (brown) and counterstained with hematoxylin (blue)

Kallikrein 11 staining of paraffin-embedded human breast cancer tissue sections using 8 µg/mL of antibody. Tissues were stained with HRP-DAB (brown) and counterstained with hematoxylin (blue)

Kallikrein 11 staining of paraffin-embedded human breast cancer tissue sections using 8 µg/mL of antibody. Tissues were stained with HRP-DAB (brown) and counterstained with hematoxylin (blue)

Kallikrein 11 staining of paraffin-embedded human breast cancer tissue sections using 8 µg/mL of antibody. Tissues were stained with HRP-DAB (brown) and counterstained with hematoxylin (blue)