C-Reactive Protein (CRP) promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to hosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL-1 and IL-6. MISCELLANEOUS: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.
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