Product Details
Catalog Number: MO15047
Applications: WB, IHC, E
Type: Mouse IgG
Dilutions: 8 ug/ml; 1-2 ug/ml; 0.5-1.0 ug/ml
Immunogen: Recombinant human Nerve Growth Factor Receptor
Storage: Antibody can be aliquotted and stored frozen at -20° C to -70° C in a manual defrost freezer for six months without detectable loss of activity. The antibody can be stored at 2° - 8° C for 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human
Entrez: 4804
UniProt: P08138
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$255.00Add to Cart

NGF R is a type I transmembrane protein that belongs to the tumor necrosis factor receptor and has been designated TNFRSF16. This receptor is also known as p75 NTR (neurotrophin receptor) because of its ability to bind at low affinity not only to NGF, but also other neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5. NGF R is a 75 kDa protein that is expressed in neuronal axons, Schwann’s cells and perineural cells of peripheral nerves. Neural crest stem cells have been isolated based on their surface expression of NGF R. In addition, neuroepithelial-derived NGF R positive cells have also been demonstrated to be able to differentiate into neurons, smooth muscle and Schwann cells in culture. Recently, NGF R has been used as a marker to identify mesenchymal precursors as well as hepatic stellate cells.

Images

NGF R in Human Brain (cortex).

NGF R in Human Brain (cortex).

Expression of receptors for brain-derived neurotrophic factor (BDNF) in human airway smooth muscle (ASM) cells. Under control conditions, both tropomyosin-related kinase (TrkB) and p75NTR receptors were expressed. Transfection of ASM cells with small interfering RNA (siRNA) specifically decreased expression of TrkB and p75NTR. Read More: http://www.atsjournals.org/doi/full/10.1165/rcmb.2008-0151OC.

Expression of receptors for brain-derived neurotrophic factor (BDNF) in human airway smooth muscle (ASM) cells. Under control conditions, both tropomyosin-related kinase (TrkB) and p75NTR receptors were expressed. Transfection of ASM cells with small interfering RNA (siRNA) specifically decreased expression of TrkB and p75NTR. Read More: http://www.atsjournals.org/doi/full/10.1165/rcmb.2008-0151OC.