Product Details
Catalog Number: MO15049
Applications: ICC, WB, IHC, E
Type: Mouse IgG
Dilutions: ICC 10ug/ml; IHC 10 ug/ml; WB 1-2 ug/ml; E 0.5-1.0 ug/ml
Immunogen: Recombinant human Musashi-1 (a.a. 1-362)
Storage: Antibody can be aliquotted and stored frozen at -20° C to -70° C in a manual defrost freezer for six months without detectable loss of activity. The antibody can be stored at 2° - 8° C for 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human
Entrez: 4440
UniProt: O43347
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ug$255.00Add to Cart

Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia and Parkinson's. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 other neurodegenerative diseases Alzheimer's disease and Pick disease suggests that it may play a role in the pathogenesis of these neurodegenerative disorders.

Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be a vital role in the development of several types of carcinoma such as human hepatoma and may be a useful molecular marker for tumor detection.

Images
Musashi-1 immunoreactivity in human brain tissue using mouse anti-human Musashi-1 monoclonal antibody (Red); counterstained with Fluoro Nissl (green).

Musashi-1 immunoreactivity in human brain tissue using mouse anti-human Musashi-1 monoclonal antibody (Red); counterstained with Fluoro Nissl (green).

Musashi-1 immunoreactivity in human brain tissue using mouse anti-human Musashi-1 monoclonal antibody (Red); counterstained with Fluoro Nissl (green).

Musashi-1 immunoreactivity in human brain tissue using mouse anti-human Musashi-1 monoclonal antibody (Red); counterstained with Fluoro Nissl (green).