Human IL-2 R alpha, also known as Tac antigen and as CD25, is a 272 amino acid (aa) precursor type I membrane protein with a 21 aa signal peptide, a 219 aa extracellular region, a 19 aa transmembrane region, and a 13 aa cytoplasmic domain. By itself, IL 2 R alpha binds IL-2 with low affinity. However, when IL-2 R alpha is associated with IL-2 R beta and the common gamma chain, a high affinity heterotrimeric receptor complex that transduces IL-2 signals is formed.
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