Chemokine receptors are seven-transmembrane domain G-protein coupled receptors that mediate the biological activities of chemokines. Most of these receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. They are named according to the chemokine subfamily they bind. There are currently six CXC-specific receptors designated CXCR1 to CXCR6, eleven CC-specific receptors designated CCR1 to CCR11, and one C receptor, XCR1. CX3CR1 is the receptor for fractalkine.
Neutralization of Human Cell Surface CXCR2 mediated Bioactivity - See download
The exact concentration of antibody required to neutralize human cell surface CXCR2 mediated bioactivity is dependent on the concentration as well as on the number of CXCR2 receptors present on the cell surface (a function of cell type and culture conditions). The Neutralization Dose50 (ND50) for this antibody is defined as that concentration of antibody required to yield one-half maximal inhibition of the cell surface CXCR2 mediated rhGROα response on responsive cells at a specific GROα concentration. The ND50 for this lot of anti-human CXCR2 antibody was determined to be approximately 1 - 5 µg/mL in the presence of 5 ng/mL rhGROα in a chemotaxis assay using BaF/3 cells transfected with hCXCR2. The specific conditions are described in the figure legends. The ND50 for the neutralization of myeloperoxidase release from human granulocytes is 0.5 - 1.5 µg/mL in the presence of 1 µg/mL rhGROα.
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Name Catalog # Size CCR1/CD191 MO15088 100 ug CCR5 MO15077 100 ug CCR6 MO15087 100 ug CXCR1/IL-8 RA MO15072 100 ug CXCR1/IL-8 RA MO15072 500 ug CXCR1/IL-8 RA-Fluorescein Labeled FC15001 100 Tests CXCR2/IL-8 RB MO15084 100 ug CXCR2/IL-8 RB-Fluorescein Labeled FC15002 100 Tests CXCR4 MO15022 100 ug CXCR4-Phycoerythrin Labeled FC15004 100 Tests IL-1 R1/CD121a GT15109 100 ug IL-10 R alpha GT15185 100 ug IL-2 R alpha/CD35 MO15070 100 ug