Chemokine receptors are seven-transmembrane domain G-protein coupled receptors that mediate the biological activities of chemokines. Most of these receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. They are named according to the chemokine subfamily they bind. There are currently eleven CC-specific receptors designated CCR1 to CCR11.
CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
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Name Catalog # Size CCR1/CD191 MO15088 100 ug CCR6 MO15087 100 ug CXCR1/IL-8 RA MO15072 100 ug CXCR1/IL-8 RA MO15072 500 ug CXCR1/IL-8 RA-Fluorescein Labeled FC15001 100 Tests CXCR2/IL-8 RB MO15073 100 ug CXCR2/IL-8 RB MO15084 100 ug CXCR2/IL-8 RB-Fluorescein Labeled FC15002 100 Tests CXCR4 MO15022 100 ug CXCR4-Phycoerythrin Labeled FC15004 100 Tests IL-1 R1/CD121a GT15109 100 ug IL-10 R alpha GT15185 100 ug IL-2 R alpha/CD35 MO15070 100 ug