Product Details
Catalog Number: MO15081
Applications: WB, FC
Type: Mouse IgG
Immunogen: Hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, Sf21-derived, recombinant human insulysin/insulin degrading enzyme (rhIDE; Accession # NP_004960, aa 42 – 1019). Clone#: 334501.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Primate
Entrez: 3416
UniProt: P14735
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ug$255.00Add to Cart

Insulysin, a widely expressed protein,  is responsible for the degradation of insulin in cells. Primarily located in the cytosol,  insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B-chain, glucagon, denatured hemoglobin, alpha-amyloid protein, TGF-alpha, and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain and has generated much interest in Alzheimer's disease research.

Images
HeLa cells were stained with anti-Insulysin (filled histogram) or isotype control (open histogram) followed by APC-conjugated rat antibody

HeLa cells were stained with anti-Insulysin (filled histogram) or isotype control (open histogram) followed by APC-conjugated rat antibody

HeLa cells were stained with anti-Insulysin (filled histogram) or isotype control (open histogram) followed by APC-conjugated rat antibody

HeLa cells were stained with anti-Insulysin (filled histogram) or isotype control (open histogram) followed by APC-conjugated rat antibody