Product Details
Catalog Number: MO15100
Applications: WB, IHC, E
Type: Mouse IgG
Immunogen: Hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, Sf 21-derived, recombinant human DDC (rhDDC; aa 1 - 480; Accession # P20711).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human, Rat
Entrez: 1644
UniProt: P20711
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$255.00Add to Cart

Dopa decarboxylase (DDC), also known as AADC, is a homodimeric vitamin B6-dependent enzyme that catalyzes the decarboxylation of hydroxylated aromatic amino acids (Accession # P20711). DDC is expressed in the adrenal medulla and catecholaminergic neurons. It catalyzes the final step in the synthesis of the neurotransmitters dopamine and serotonin. Defects in DDC are associated with the development of schizophrenia, Parkinson's disease, and hypertension. Human DDC shares 89% aa sequence identity with mouse and rat DDC.

Images
DOPA decarboxylase  staining of  paraffin-embedded human caudate sections (dilution: 25 µg/ml). Tissue was stained using HRP-DAB (brown) and counterstained with hematoxylin (blue).

DOPA decarboxylase staining of paraffin-embedded human caudate sections (dilution: 25 µg/ml). Tissue was stained using HRP-DAB (brown) and counterstained with hematoxylin (blue).

DOPA decarboxylase  staining of  paraffin-embedded human caudate sections (dilution: 25 µg/ml). Tissue was stained using HRP-DAB (brown) and counterstained with hematoxylin (blue).

DOPA decarboxylase staining of paraffin-embedded human caudate sections (dilution: 25 µg/ml). Tissue was stained using HRP-DAB (brown) and counterstained with hematoxylin (blue).