Product Details
Catalog Number: MO15108
Applications: WB, IHC, E, FC
Type: Mouse IgM
Immunogen: Hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, CHO cell-derived, recombinant Transforming Growth Factor beta 1 (TGF-b1) and latent TGF-b1.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Primate
Entrez: 8243
UniProt: Q14638
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$255.00Add to Cart

Structural Maintenance of Chromosome 1 (SMC1) is an ATPase which, with SMC3, forms a heterodimeric complex. These dimers form a V-shaped molecule with two long coiled-coil arms, each having an ATP-binding domain at its distal end. The SMC1/SMC3 heterodimer plays an important role in sister chromatid cohesion during metaphase, associates with the nuclear matrix and centrosome during interphase and localizes to kinetochores, spindles and spindle poles during mitosis. Smc1 is also a component of the DNA damage response and participates in the cellular response to DNA damage through its phosphorylation on Ser 957 and 966.

Inhibition of SMC1 is associated with chromosomal aberrations. These aberrations play a role in developmental disorders like autism.

Images

Detection of SMC1 in Western Blot. Extracts from exponentially growing U2-OS (human), Balb/c-3T3 (mouse), and normal rat kidney (NRK) cells were prepared, resolved by SDS-PAGE, and transferred to a PVDF membrane. The membrane was immunoblotted with 0.25 μg/mL monoclonal anti-SMC1 antibody.

Detection of SMC1 in Western Blot. Extracts from exponentially growing U2-OS (human), Balb/c-3T3 (mouse), and normal rat kidney (NRK) cells were prepared, resolved by SDS-PAGE, and transferred to a PVDF membrane. The membrane was immunoblotted with 0.25 μg/mL monoclonal anti-SMC1 antibody.