Product Details
Catalog Number: MO15109
Applications: ICC, IHC, FC
Type: Mouse IgG
Immunogen: Hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with NS0 cells transfected with human SSTR2 (hSSTR2; aa 1 - 369; Accession # P30874).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human
Entrez: 6752
UniProt: P30874
Downloads: Datasheet (pdf)
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Three types of opioid receptors have been cloned -- mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N- and C-termini. Activation of mu opioid receptors leads to a decrease in neuronal excitability.

Kappa Opioid Receptor (KOR) is a 45 kDa 7TM opioid receptor that is primarily expressed in the central nervous system and peripheral visceral pain sensory nerves. Following ligation by dynorphin peptides, KOR signaling induces analgesia, dysphoria, diuresis, and increased feeding desire. KOR also exerts neuroprotective and anti-inflammatory effects.

Images
MDA-MB-231 cells were stained with anti-SSTR2 (filled histogram) or isotype control antibody (open histogram), followed by APC-conjugated anti-mouse antibody.

MDA-MB-231 cells were stained with anti-SSTR2 (filled histogram) or isotype control antibody (open histogram), followed by APC-conjugated anti-mouse antibody.

MDA-MB-231 cells were stained with anti-SSTR2 (filled histogram) or isotype control antibody (open histogram), followed by APC-conjugated anti-mouse antibody.

MDA-MB-231 cells were stained with anti-SSTR2 (filled histogram) or isotype control antibody (open histogram), followed by APC-conjugated anti-mouse antibody.