SOX10 is a member of the SRY-related HMG-box family of transcription factors. It is required for the terminal differentiation of oligodendrocytes and myelination. In the peripheral nervous system, SOX10 maintains pluripotency of neural crest stem cells and suppresses neuronal differentiation.
The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
Note: This antibody was selected for its ability to detect rat SOX10 in immunohistochemistry experiments. Epitope-mapping experiments indicated that clone 20B7 recognizes a determinant in the first 65 amino acids, which contains sequences unique to SOX101.
1. Lo, L. et al., 2002, Development 129:1553 - 1567.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size SOX-10 MO47006 100 ug SOX-2/SRY (sex determining region Y)-box 2 MO47038 100 ul SOX1 GT15208 100 ug SOX10 GT15218 100 ug. SOX17 GT15094 100 ug SOX2 GT15098 100 ug. SOX2 MO15040 100 ug SOX2 RA25021 100 ul SOX21 GT15209 100 ug SOX3 GT15119 100 ug SOX6 RA19023 100 ug SOX7 MO15050 100 ug SOX7 MO15050 50 ug SOX9 GT15207 100 ug SRY (Sex Determining Region Y)-Box 11/SOX-11 MO47052 100 ul