CEACAM-1 (BGP-1 or CD66a) belongs to the carcinoembryonic antigen (CEA) gene family. This antibody is an excellent for cells of epithelial and myeloid origin.
CEACAM-1 expression is downregulated in many tumors indicating a tumor - suppressive function. The antitumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of antiangiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM-1 differs from those found in other CEACAM.
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