Product Details
Catalog Number: MO15128
Applications: IP, IF
Type: Mouse IgG
Immunogen: A synthetic peptide corresponding to the C-terminus of human Osteopontin [Swiss-Prot# P10451].
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human, Rat
Entrez: 632
UniProt: P02818
Downloads: Datasheet (pdf)
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Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein found in bone and dentin. Osteocalcin is a marker for osteogenesis. It can be used to determine the differentaition state as mesenchymal stem cells differentiate from osteocytes to osteoblasts.

It is also implicated in bone mineralization and calcium ion homeostasis. Osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin

Images

Osteocalcin staining of immersion fixed Paraffin embedded sections of human cartilage tissue (brown) using Human at 8 μg/mL overnight at 4 °C. and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of chondrocytes. Protocol on Datasheet.

Osteocalcin staining of immersion fixed Paraffin embedded sections of human cartilage tissue (brown) using Human at 8 μg/mL overnight at 4 °C. and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of chondrocytes. Protocol on Datasheet.

Image: Osteocalcin staining of human mesenchymal stem cells differentiated into osteocytes (red) at 10 μg/mL for 3 hours at room temperature and counterstained with DAPI (blue). Protocol on Datasheet.

Image: Osteocalcin staining of human mesenchymal stem cells differentiated into osteocytes (red) at 10 μg/mL for 3 hours at room temperature and counterstained with DAPI (blue). Protocol on Datasheet.

Image: Osteocalcin staining of human mesenchymal stem cells differentiated into osteocytes (red) at 10 μg/mL for 3 hours at room temperature and counterstained with DAPI (blue). Protocol on Datasheet.

Image: Osteocalcin staining of human mesenchymal stem cells differentiated into osteocytes (red) at 10 μg/mL for 3 hours at room temperature and counterstained with DAPI (blue). Protocol on Datasheet.